Andon Hestiantoro

Daftar Karya Ilmiah

Daftar Karya Ilmiah Hasil Penelitian yang dipublikasikan sebagai penulis utama :

  1. Andon Hestiantoro , Budianto Barnas, MHR Sianturi. Penilaian adekuasi spesimen tes Pap dengan menggunakan spatula Lonstenn. Maj Obstet Ginekol Indones 1996; 20 (2): 101-8
  2. Andon Hestiantoro, Dick F. Swaab. Changes in Estrogen Receptor-α and -β in the Infundibular Nucleus ot the Human Hypothalamus Are Related to The Occurrence  of Alzheimer’s Disease Neuropathology. The Journal of Endocrynology & Metabolism April 2004, 89(4):1912-1925.
  3. Andon Hestiantoro, Budi Wiweko, Hendy Hendarto, Djaswadi Dasuki, Tono Djuwantono. Buku Panduan Perdarahan Uterus Disfungsional. HIFERI-POGI. Juli 2007.

Daftar Karya Ilmiah Hasil Penelitian Yang di Publikasikan Sebagai Penulis Pembantu :

  1. Ali Baziad, Andon Hestiantoro. Pengukuran ketebalan kulit untuk deteksi dini osteoporosis dengan USG transdermal pada wanita menopause yang mendapat terapi substitusi. Majalah Obstetri & Ginekologi Indonesia, Vol. 21 No.2, hal.109-113, April 1997.
  2. Bayu Winarno, Ichramsjah A. Rachman, Andon Hestiantoro. Densitas mineral tulang wanita menyusui. Maj Obstet Ginekol Indones 1998; 22 (4): 170-6
  3. Damar Prasmusinto, Andon Hestiantoro, T.Z. Jacoeb.Terapi hormon pengganti pada pasien Sindrom Turner (laporan kasus). Majalah Obstetri & Ginekologi Indonesia, Vol. 22, hal: 97-142, Juli 1998.
  4. Akam Pertamawan, Andon Hestiantoro. Manfaat fitoestrogen Isoflavon pada wanita menopause. Majalah Obstetri & Ginekologi Indonesia, Vol. 26  No.1, hal:1-58, Januari 2002.
  5. Swaab DF, Chung WC, Kruijver FP, Hofman MA, Hestiantoro A. Sex differences in the hypothalamus in the different stages of human life. Neurobiol Aging. 2003; 24 Suppl 1:S1-16; discussion S17-9.

Colocalization of corticotropin-releasing hormone and oestrogen receptor-{alpha} in the paraventricular nucleus of the hypothalamus in mood disorders (2005)

Summary Oestrogens may modulate the activity of the hypothalamic-pituitary-adrenal (HPA) axis. The present study was to investigate whether the activity of the HPA axis in mood disorders might be directly modulated by oestrogens via oestrogen receptors (ORs) in the corticotropin-releasing hormone (CRH) neurons of the human hypothalamic paraventricular nucleus (PVN). Brains of 13 subjects ranging in age between 45 and 79 years suffering from major depression/major depressive disorder (eight cases) or bipolar disorder (five cases) and of 13 controls, matched for sex, age, brain weight, post-mortem delay, fixation time and season and clock time at death, were studied with double-label immunocytochemistry. The total number of CRH-immunoreactive (IR) neurons, CRH neurons that colocalized ORα in the neuronal nucleus and the number of only nuclear ORα-containing neurons in the PVN were measured using an image analysis system. In addition, the volume of the PVN delineated on the basis of CRH neurons was determined. It was found that the total number of CRH-IR neurons in patients with mood disorders was nearly 1.7 times higher than in controls (P = 0.034). A novel finding was that the total number of CRH-IR neurons and the number of CRH-nuclear ORα double-staining neurons in the PVN were strongly correlated both in controls and in patients with mood disorders (P < 0.001 and P = 0.022, respectively). The ratio of the CRH-nuclear-ORα double-staining neurons to the total CRH-IR neurons in patients with mood disorders was similar to that in the controls (P = 0.448). The volume of the sub-region of the PVN that was delineated on the basis of CRH neurons was significantly larger in patients with mood disorders than in controls (P = 0.022). Another novel finding was the large population of extra-hypothalamic CRH neurons that was found in the thalamus. In summary, oestrogens may directly influence CRH neurons in the human PVN. The increased numbers of neurons expressing CRH in mood disorders is accompanied by increased ORα colocalization in the nucleus of these neurons. These changes seem to be trait- rather than state- related

Naskah lengkap dapat diunduh disini…..1301

Changes in Estrogen Receptor-{alpha} and -ß in the Infundibular Nucleus of the Human Hypothalamus Are Related to the Occurrence of Alzheimer’s Disease Neuropathology
Andon Hestiantoro and Dick F. Swaab

The expression of estrogen receptor (ER){alpha} and -ß in the infundibular nucleus of the hypothalamus was studied immunocytochemically in 28 control subjects and 14 patients with Alzheimer’s disease (AD). A shift was found from more nuclear staining of ER{alpha} in young female controls to more cytoplasmic staining in elderly female controls, whereas no such change was observed in elderly male controls. The shift of ER{alpha} from nucleus to cytoplasm in elderly female controls was accompanied by a relative absence of AD neuropathology, i.e. hyperphosphorylated tau stained by hyperphosphorylated tau protein (AT8). In contrast, male and female AD patients showed more nuclear ER{alpha} and a much stronger AD neuropathology. It is proposed that the shift of ER{alpha} from nucleus to the cytoplasm may reflect activation of neurons and that hyperactivity decreases the risk that neurons in the course of aging develop AD neuropathology. In contrast, the presence of nuclear ER{alpha} seems to predispose to reduced activity and increases the risk of some neurons to develop AD neuropathology. ERß in basket-like terminals was preferentially observed in elderly male controls and AD patients, a novel phenomenon. This suggests that the presence of basket-like ERß may reflect reduced activity, which is-associated with an increase in hyperphosphorylated tau staining. However, the neurons inside the basket-like ERß showed signs of hyperactivity and did not stain for AT8. All AT8-positive neurons in the infundibular nucleus contained {alpha}MSH as a marker for proopiomelanocortin neurons. These neurons produce ß-endorphin that inhibits GnRH release. Because they diminish in activity in postmenopausal women, this may contribute to the hyperactivity of GnRH neurons. The regulation of the gonadal axis may thus be affected by AD neuropathology independent of AD neuropathology in cognition-related brain structures.

Naskah lengkap dapat diunduh disini…..1912


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